Long-term outcomes in conservatively treated twin-to-twin transfusion syndrome
Author Information
Author(s): Li Xiangqun, Morokuma Seiichi, Fukushima Kotaro, Otera Yuka, Yumoto Yasuo, Tsukimori Kiyomi, Ochiai Masayuki, Hara Toshiro, Wake Norio
Primary Institution: Kyushu University
Hypothesis
What are the long-term neurodevelopmental outcomes in conservatively treated twin-to-twin transfusion syndrome?
Conclusion
The study found a high rate of perinatal mortality and significant neurodevelopmental impairment in conservatively treated twin-to-twin transfusion syndrome, but better outcomes for survivors delivered after 29 weeks of gestation.
Supporting Evidence
- 30% of surviving twins had neurodevelopmental impairment.
- 42.9% perinatal mortality rate was observed.
- 20% of children had major neurodevelopmental impairment.
- Better outcomes were noted for survivors delivered after 29 weeks of gestation.
Takeaway
When twins have a condition called twin-to-twin transfusion syndrome, many don't survive, and some who do may have problems later, especially if they are born too early.
Methodology
The study reviewed prenatal and neonatal records of all pregnancies with twin-to-twin transfusion syndrome admitted to a center over nine years, evaluating gestational age, treatment methods, and neurodevelopmental outcomes.
Potential Biases
Potential bias may arise from the observational nature of the study and the lack of a control group.
Limitations
The study had a small sample size and focused on a specific treatment method, which may limit the generalizability of the findings.
Participant Demographics
The study included pregnancies with twin-to-twin transfusion syndrome admitted to a single center over a nine-year period.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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