C5aR1-positive adipocytes help newborn mice stay warm
Author Information
Author(s): Wang Huan-Yu, Peng Xue-Min, Yang Min, Weng Ying, Yang Xi, Zhan Di, Ning Qin, Luo Xiao-Ping, Chen Yong
Primary Institution: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Hypothesis
C5aR1-positive brown adipocytes are essential for thermoregulation in neonatal mice.
Conclusion
C5aR1-positive brown adipocytes are crucial for maintaining body temperature in newborn mice by regulating thermogenesis.
Supporting Evidence
- C5aR1 deficiency in brown adipose tissue led to cold intolerance in neonatal mice.
- Loss of C5aR1 in CD45+ adipocytes increased PF4 secretion, inhibiting the maturity of neighboring brown adipocytes.
- CD45+ adipocytes exhibited lower thermogenic gene expression compared to classical brown adipocytes.
Takeaway
Some special cells in baby mice help them stay warm by producing heat, and if these cells don't work right, the baby mice get cold.
Methodology
Single-cell RNA sequencing was used to analyze stromal vascular fraction cells from brown adipose tissue of neonatal mice.
Limitations
The in vivo roles of CD45+ adipocytes need further exploration through loss or gain experiments.
Participant Demographics
Neonatal mice (postnatal day 1).
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website