Study of CART Neurons in Pigs
Author Information
Author(s): Wierup Nils, Gunnarsdóttir Anna, Ekblad Eva, Sundler Frank
Primary Institution: Lund University, Lund, Sweden
Hypothesis
CART is expressed in the porcine pancreas, gastrointestinal tract, adrenal glands, and thyroid gland.
Conclusion
CART is a major neuropeptide in intrinsic neurons of the porcine GI-tract and pancreas, a major constituent of adrenaline producing adrenomedullary cells, and a novel peptide of the thyroid C-cells.
Supporting Evidence
- CART is found in numerous nerve fibers and cell bodies in the porcine pancreas and GI tract.
- The majority of CART IR cells in the adrenal medulla are also adrenaline producing.
- CART is expressed in C-cells of the thyroid gland.
Takeaway
This study looked at a special protein called CART in pigs to see where it is found in their bodies. They found it in important places like the pancreas and adrenal glands.
Methodology
The study used immunocytochemistry to map CART expression in various tissues from adult domestic pigs.
Limitations
The study is limited to adult domestic pigs and may not be generalizable to other species.
Participant Demographics
Adult domestic pigs, age: 17 months, of both genders.
Digital Object Identifier (DOI)
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