Biological effects of naturally occurring and man-made fibres: in vitro cytotoxicity and mutagenesis in mammalian cells
1999
Effects of Natural and Man-Made Fibres on Cells
publication
Author Information
Author(s): Okayasu R, Wu L, Hei T K
Primary Institution: Department of Radiation Oncology, Biology Division, Galveston, TX, USA
Hypothesis
How do naturally occurring and man-made fibres affect cytotoxicity and mutagenesis in mammalian cells?
Conclusion
RCF-1 fibres are non-genotoxic, while erionite shows significant mutagenic potential.
Supporting Evidence
- Tremolite, erionite, and RCF-1 fibres were less cytotoxic to A L cells than chrysotile.
- Erionite induced a significantly higher mutant yield than tremolite.
- RCF-1 fibres were largely non-mutagenic.
Takeaway
This study looked at how different types of fibres affect cells. Some fibres are harmful, while others are not.
Methodology
Cytotoxicity and mutagenicity were studied using human-hamster hybrid A L cells.
Digital Object Identifier (DOI)
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