KIAA0247 as a Modulator in Colorectal Cancer Treatment
Author Information
Author(s): Huang Chi-Jung, Yang Shung-Haur, Huang Shih-Ming, Lin Chih-Ming, Chien Chih-Cheng, Chen Yan-Chu, Lee Chia-Long, Wu Hao-Han, Chang Chun-Chao
Primary Institution: Fu Jen Catholic University
Hypothesis
The study investigates the role of KIAA0247 in colorectal cancer and its potential as a therapeutic target under 5-FU treatment.
Conclusion
KIAA0247 overexpression is linked to improved survival rates in colorectal cancer patients undergoing 5-FU treatment.
Supporting Evidence
- KIAA0247 expression was found to be higher in patients with better survival rates.
- Patients with higher fecal KIAA0247 levels had smaller tumor sizes.
- Immunofluorescent staining showed KIAA0247 accumulation in the nucleus after 5-FU treatment.
Takeaway
This study found that a protein called KIAA0247 can help doctors know which colorectal cancer patients might do better with a specific treatment.
Methodology
The study used molecular analysis of feces and cell cycle analysis in CRC cell lines to evaluate KIAA0247's role.
Participant Demographics
56 colorectal cancer patients, with follow-up data collected over a mean of 34.9 months.
Statistical Information
P-Value
0.035
Confidence Interval
95% CI, 0.55-0.92
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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