Preterm Premature Rupture of Membranes in HIV-Infected Women
Author Information
Author(s): Kjersti M. Aagaard-Tillery, Monique G. Lin, Virginia Lupo, Alan Buchbinder, Patrick S. Ramsey
Primary Institution: The University of Utah Health Sciences
Hypothesis
What are the management and outcomes of HIV-infected women whose pregnancies are complicated by preterm premature rupture of membranes?
Conclusion
The study suggests that immediate delivery may be considered in HIV+ pregnancies complicated by PPROM at an early gestational age, while expectant management may be appropriate in certain cases.
Supporting Evidence
- 2.4% of the pregnancies developed PPROM remote from term.
- Vertical HIV transmission occurred in 33% of cases where no or minimal antiviral therapy was used.
- No cases of vertical transmission occurred in women receiving multidrug therapy or HAART.
Takeaway
This study looked at pregnant women with HIV who had their water break too early. It found that some women can wait to deliver their babies safely, while others might need to deliver right away.
Methodology
A retrospective chart review of HIV-infected women with pregnancies complicated by PPROM was conducted at two medical centers.
Limitations
The study has a limited sample size and a heterogeneous population.
Participant Demographics
The study included HIV-positive women with various medical histories and demographics, including African American, Caucasian, and Latino women.
Digital Object Identifier (DOI)
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