Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide
2008
Berberine Boosts Cancer Cell Treatment with Arsenic
publication
Evidence: moderate
Author Information
Author(s): Lin Tseng-Hsi, Kuo Hsing-Chun, Chou Fen-Pi, Lu Fung-Jou
Primary Institution: Chung Shan Medical University
Hypothesis
Does berberine enhance the effects of arsenic trioxide on glioma cell migration and invasiveness?
Conclusion
Berberine significantly enhances the inhibition of glioma cell metastasis when used with arsenic trioxide.
Supporting Evidence
- Berberine enhances the antiproliferation activity of arsenic trioxide in glioma cells.
- Co-treatment with berberine and arsenic trioxide significantly reduces glioma cell migration.
- The combination treatment leads to decreased activation of protein kinase C, which is involved in cancer cell migration.
Takeaway
Berberine is a natural compound that helps make cancer treatment with arsenic more effective, especially for brain tumors.
Methodology
The study used MTT assays, wound scratch assays, and Boyden chamber assays to evaluate cell viability, migration, and invasiveness.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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