Iron Uptake Mediated by Binding of H-Ferritin to the TIM-2 Receptor in Mouse Cells
2011
Iron Uptake Mediated by TIM-2 in Mouse Cells
publication
Evidence: moderate
Author Information
Author(s): Han Jian, Seaman William E., Di Xiumin, Wang Wei, Willingham Mark, Torti Frank M., Torti Suzy V.
Primary Institution: Wake Forest School of Medicine
Hypothesis
Can ferritin binding to TIM-2 serve as an iron delivery mechanism?
Conclusion
TIM-2 can function as an iron uptake pathway, allowing iron from ferritin to enter cells and become metabolically available.
Supporting Evidence
- TIM-2 was shown to mediate the uptake of iron-loaded ferritin in mouse kidney cells.
- Iron uptake was specific to TIM-2 positive cells and was temperature-dependent.
- Iron delivered via TIM-2 increased levels of intracellular ferritin.
Takeaway
This study shows that a protein called TIM-2 helps cells take in iron from ferritin, which is important for their health.
Methodology
The study involved transfecting mouse kidney cells with TIM-2 and measuring iron uptake from labeled ferritin.
Digital Object Identifier (DOI)
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