Functional Organization of Mammalian Chromosomes
Author Information
Author(s): Petko M. Petkov, Joel H. Graber, Gary A Churchill, Keith DiPetrillo, Benjamin L. King, Kenneth Paigen
Primary Institution: The Jackson Laboratory
Hypothesis
The mammalian genome contains blocks of functionally related genes.
Conclusion
The recalculated results provide additional support for the original conclusions regarding the functional organization of mammalian genomes.
Supporting Evidence
- The recalculated genetic map length is 14.7% shorter than previous estimates.
- Communication with the authors of the challenged study confirmed the new results.
Takeaway
Scientists found that genes in mammals are organized in blocks that work together, and new calculations support this idea.
Methodology
Revised calculations of genetic distances using a specific methodology.
Limitations
The initial findings were challenged due to inappropriate data inclusion in the analysis.
Participant Demographics
Authors are affiliated with The Jackson Laboratory and Novartis.
Statistical Information
Confidence Interval
1393 ± 14 cM
Digital Object Identifier (DOI)
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