Septal agenesis and lissencephaly with colpocephaly presenting as the ‘Crown Sign’
2010
Crown Sign in Neuronal Migration Disorder
Sample size: 1
publication
Evidence: low
Author Information
Author(s): Namit Singhal, Sunil Agarwal
Primary Institution: Heritage Hospital, Agra, India
Hypothesis
Can a unique imaging appearance be identified in a case of neuronal migration disorder?
Conclusion
The study describes a unique imaging finding called the 'Crown Sign' associated with a triad of lissencephaly, colpocephaly, and septal agenesis.
Supporting Evidence
- The child presented with delayed developmental milestones and seizures.
- CT scan revealed lissencephaly, colpocephaly, and septal agenesis.
- The unique appearance of the ventricular system was referred to as the 'Crown Sign'.
- The child showed gradual improvement with treatment.
Takeaway
This study shows that a child's brain can look like a crown on a scan if they have certain brain problems.
Methodology
A case study involving a 2-year-old male child with imaging studies and clinical follow-up.
Limitations
The study is based on a single case, limiting generalizability.
Participant Demographics
A 2-year-old male child.
Digital Object Identifier (DOI)
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