Gait Analysis in Prader-Willi Syndrome Patients
Author Information
Author(s): Vismara Luca, Romei Marianna, Galli Manuela, Montesano Angelo, Baccalaro Gabriele, Crivellini Marcello, Grugni Graziano
Primary Institution: Istituto Scientifico Ospedale San Giuseppe, Verbania, Italy
Hypothesis
The study aims to analyze the gait pattern of adult subjects with Prader-Willi Syndrome (PWS) and compare it with obese and healthy subjects.
Conclusion
PWS subjects had a significantly different gait pattern compared to obese patients, despite both groups having a similar BMI.
Supporting Evidence
- PWS patients walked slower and had a shorter stride length compared to both obese and healthy subjects.
- Obese matched patients showed spatio-temporal parameters significantly different from healthy subjects.
- PWS subjects had a longer stance phase and a lower cadence compared to both control groups.
Takeaway
People with Prader-Willi Syndrome walk differently than those who are just obese, even if they weigh the same. This is because of how their bodies develop when they are young.
Methodology
A cross-sectional comparative study using three-dimensional gait analysis to assess kinematic and kinetic parameters during walking.
Potential Biases
Potential selection bias due to the specific recruitment of patients from a single institution.
Limitations
The study may not account for long-term effects of obesity on gait as it only analyzes adult patients.
Participant Demographics
19 patients with PWS (11 males, 8 females, aged 18-40 years), 14 matched obese patients (5 males, 9 females, aged 18-40 years), and 20 healthy subjects (10 males, 10 females, aged 21-41 years).
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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