CD14 Gene and Asthma: A Meta-Analysis
Author Information
Author(s): Zhao Linlu, Bracken Michael B
Primary Institution: Yale School of Public Health
Hypothesis
Is there an association between the CD14 -260C>T genotype and asthma susceptibility?
Conclusion
The study found a protective relationship between the CD14 -260T allele and atopic asthma susceptibility.
Supporting Evidence
- Carriers of the TT genotype were about 33% less likely to have atopic asthma compared to CC genotype carriers.
- Carriers of the CT genotype were about 20% less likely to have atopic asthma compared to CC genotype carriers.
- The study included a total of 4780 genotyped asthma cases and 5650 genotyped non-asthmatic controls.
Takeaway
This study looked at a gene that might help protect against asthma. It found that some people with a certain gene type are less likely to have asthma.
Methodology
A systematic review and meta-analysis of 23 studies was conducted to estimate the association between the CD14 -260C>T SNP and asthma.
Potential Biases
Some studies showed deviation from Hardy-Weinberg equilibrium, indicating potential selection bias.
Limitations
The study faced challenges due to high heterogeneity among studies and inadequate reporting of methodology in some studies.
Participant Demographics
The meta-analysis included studies from various ethnic groups, including European, East Asian, and Indian populations.
Statistical Information
Confidence Interval
95% CI: 0.54-0.84 for TT genotype; 95% CI: 0.66-0.95 for CT genotype
Digital Object Identifier (DOI)
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