Overview of Enterovirus Infections in Marseille Hospitals (1985–2005)
Author Information
Author(s): Tan Charlene Y. Q., Ninove Laetitia, Gaudart Jean, Nougairede Antoine, Zandotti Christine, Thirion-Perrier Laurence, Charrel Remi N., de Lamballerie Xavier
Primary Institution: UMR190 Unite des Virus Emergents, Universite de la Méditerranee - Institut de Recherche pour le Développement, Marseille, France
Hypothesis
What are the trends in enterovirus infections and their serotypes in Marseille hospitals over a 20-year period?
Conclusion
The study found that Enterovirus E30 was the most frequently isolated serotype, with significant seasonal peaks in isolation frequency.
Supporting Evidence
- 98% of characterized isolates belonged to species HEV-B.
- E30 was the most frequently isolated serotype, accounting for 50.3% of isolates in 2000.
- Stool samples allowed detection of all identified serotypes.
- Peak HEV isolation occurred mostly in late spring and summer months.
- Seroneutralization-based serotype identification showed 55.4% accuracy compared to molecular analysis.
Takeaway
Doctors looked at a lot of samples from sick people in Marseille over 20 years to see which types of enteroviruses were making them sick, and they found that one type, E30, was the most common.
Methodology
The study compiled a database of clinical HEV isolates and analyzed them for epidemiological trends and laboratory diagnostic techniques.
Potential Biases
Potential bias due to the reliance on cell culture methods which may not capture all circulating serotypes.
Limitations
The study may be limited by the biases associated with cell culture techniques and the referral of patient samples.
Participant Demographics
Clinical samples were collected from patients at the Public Hospitals of Marseille.
Statistical Information
P-Value
p<0.01
Confidence Interval
UCL99=6.71
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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