Expression of testicular genes in haematological malignancies
1999
Testicular Genes in Blood Cancers
Sample size: 107
publication
Author Information
Author(s): Lim S H, Austin S, Owen-Jones E, Robinson L
Primary Institution: Department of Haematology, University of Wales College of Medicine, Cardiff, UK
Hypothesis
What is the expression of cancer/testis antigens in haematological malignancies?
Conclusion
The study found that the SCP1 antigen is present in a small percentage of certain blood cancers, while two other antigens were not detected at all.
Supporting Evidence
- SCP1 transcripts were found in 10% of myeloma cases.
- SCP1 transcripts were found in 5.7% of acute myeloid leukaemia cases.
- SCP1 transcripts were found in 23% of chronic myeloid leukaemia cases.
- NY-ESO-1 and SSX2 were not detected in any of the 107 tumour samples.
Takeaway
The researchers looked for specific genes in blood cancers and found one gene in a few cases, but two others were missing.
Methodology
Reverse transcription polymerase chain reaction and Southern blot analysis were used to examine the presence of transcripts for three CT antigens.
Digital Object Identifier (DOI)
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