Association of age at menopause and suicide risk in postmenopausal women: a nationwide cohort study
2024

Menopause Age and Suicide Risk in Women

Sample size: 1315795 publication 10 minutes Evidence: high

Author Information

Author(s): Moon Daa Un, Kim Hyewon, Jung Jin-Hyung, Han Kyungdo, Jeon Hong Jin

Primary Institution: Charité Universitätsmedizin Berlin and Samsung Medical Center

Hypothesis

Earlier onset of menopause is associated with an increased risk of suicide.

Conclusion

Women who experience menopause at an earlier age, especially those with primary ovarian insufficiency, have a higher risk of suicide.

Supporting Evidence

  • Women with primary ovarian insufficiency had a 43% higher risk of suicide.
  • Suicide risk decreased with increasing age at menopause.
  • 2,986 suicides were recorded over a 12-year follow-up period.

Takeaway

If women go through menopause early, they might feel sadder and have a higher chance of wanting to hurt themselves.

Methodology

This study analyzed data from the Korean National Health Insurance System, focusing on postmenopausal women and using Cox proportional hazards models to assess suicide risk.

Potential Biases

Potential for selection bias and underreporting of mental health conditions due to cultural stigma.

Limitations

The study's retrospective nature may lead to recall bias, and findings may not be generalizable beyond Korean women.

Participant Demographics

The cohort consisted of postmenopausal women aged 30 years and older, with a mean age of 61.7 years.

Statistical Information

P-Value

p<0.001

Confidence Interval

1.14–1.78

Statistical Significance

p<0.001

Digital Object Identifier (DOI)

10.3389/fpsyt.2024.1442991

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