Cannabidiol's Role in Reducing Retinal Inflammation
Author Information
Author(s): El-Remessy A.B., Tang Y., Zhu G., Matragoon S., Khalifa Y., Liu E.K., Liu J-Y., Hanson E., Mian S., Fatteh N., Liou G.I.
Primary Institution: Medical College of Georgia, Augusta, GA
Hypothesis
Retinal inflammation and microglia activation are initiated and sustained by oxidative stress and p38 MAPK activation, and that CBD reduces inflammation by blocking these processes.
Conclusion
CBD exerts anti-inflammatory and neuroprotective effects by blocking oxidative stress and activation of p38 MAPK and microglia.
Supporting Evidence
- CBD treatment inhibited ROS formation and p38 MAPK activation.
- LPS treatment increased TNF-α production, which was blocked by CBD.
- CBD reduced oxidative stress and neuronal apoptosis in uveitis models.
- CBD showed significant effects in preventing retinal inflammation.
- Microglial activation was significantly reduced with CBD treatment.
- CBD treatment resulted in lower levels of nitrotyrosine in retinas.
- CBD blocked the activation of p38 MAPK in retinal cells.
- CBD prevented the increase of NO levels in retinal microglial cells.
Takeaway
This study shows that a compound called CBD can help protect the eyes from damage caused by inflammation.
Methodology
Microglial cells were isolated from newborn rats and treated with LPS and CBD to measure various inflammatory markers.
Participant Demographics
Inbred male, 8-10-week-old Sprague-Dawley rats.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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