Clindamycin-Resistant C. difficile Clone of PCR Ribotype 027 in Europe
Author Information
Author(s): Drudy Denise, Goorhuis Bram, Bakker Dennis, Kyne Lorraine, van den Berg Renate, Fenelon Lynda, Fanning Seamus, Kuijper Edward J.
Primary Institution: University College Dublin, Dublin, Ireland
Hypothesis
Is clindamycin resistance in C. difficile PCR ribotype 027 emerging in Europe?
Conclusion
Clindamycin-resistant C. difficile PCR 027 strains have been identified in multiple healthcare settings in Ireland, indicating a worrying development in the spread of this pathogen.
Supporting Evidence
- Over 100 Irish C. difficile 027 isolates were characterized.
- Clindamycin-resistant isolates were identified in 5 healthcare institutions.
- All clindamycin-resistant PCR 027 isolates were positive for the ermB gene.
Takeaway
Some germs that make people sick are becoming resistant to medicine. This study found that a specific germ called C. difficile is not responding to a medicine called clindamycin in some places in Ireland.
Methodology
The study characterized C. difficile isolates using antibiogram profiles, toxinotyping, and MLVA.
Limitations
The study may not represent all healthcare settings in Europe, and the resistance mechanisms were not fully explored.
Participant Demographics
Isolates were collected from multiple healthcare settings in Ireland.
Digital Object Identifier (DOI)
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