Lipoprotein Lipase Gene and Combined Hyperlipidemia
Author Information
Author(s): Wung Shu-Fen, Kulkarni Medha V, Pullinger Clive R, Malloy Mary J, Kane John P, Aouizerat Bradley E
Primary Institution: University of California San Francisco
Hypothesis
Significant depletion of the 447X allele exists in combined hyperlipidemia cases versus controls.
Conclusion
The study suggests a role for the S447X polymorphism in combined hyperlipidemia and highlights the importance of evaluating both susceptibility and protective genetic risk factors.
Supporting Evidence
- The 447X allele frequency was significantly lower in cases compared to controls (0.130 vs. 0.031).
- Carriers of the 447X allele displayed significantly lower triglycerides and LDL cholesterol.
- The study found significant allelic and genotypic associations in controls and cases.
Takeaway
This study looked at a gene that helps break down fats in the body and found that people with a certain version of this gene are less likely to have high fat levels in their blood.
Methodology
A case-control design was employed, assessing the polymorphism by restriction assay in 212 cases and 161 controls.
Potential Biases
None reported.
Limitations
Potential selection bias of combined hyperlipidemia subjects and limited availability of BMI data for regression analyses.
Participant Demographics
Non-Hispanic Caucasian (European-descent) subjects.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI: 0.096–0.378
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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