Transfer of AA Amyloidosis
Author Information
Author(s): Sponarova Jana, Nyström Sofia N., Westermark Gunilla T.
Primary Institution: Linköping University, Sweden
Hypothesis
Can peripheral blood monocytes transfer AA amyloidosis?
Conclusion
Peripheral blood monocytes can carry amyloid-seed that triggers AA amyloidosis in recipient mice.
Supporting Evidence
- 19 out of 48 recipient mice developed AA amyloidosis after receiving monocytes.
- Monocytes from amyloid-laden mice contained amyloid-seed.
- Plasma from amyloidotic mice did not trigger AA amyloidosis.
Takeaway
Some white blood cells can carry a substance that makes people sick, and if you give those cells to another person, they can get sick too.
Methodology
Mice were injected with amyloid fibrils and inflammatory agents, and their blood monocytes were analyzed for amyloid-seed transfer.
Potential Biases
Technical issues in isolating monocytes could lead to underestimation of seeding activity.
Limitations
Variability in monocyte preparations may affect results.
Participant Demographics
Outbreed female NMRI mice, 6–8 weeks old.
Digital Object Identifier (DOI)
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