Serum C1-esterase inhibitor as a prognostic factor in gastric cancer
Author Information
Author(s): C.W. Janssen Jr, R.T. Lie, H. Maartmann-Moe, R. Matre
Primary Institution: University of Bergen, Bergen, Norway
Hypothesis
Is the preoperative concentration of C1-INH an independent prognostic factor for gastric carcinoma?
Conclusion
The preoperative concentration of C1-INH is a significant and independent prognostic indicator for gastric carcinoma recurrence.
Supporting Evidence
- Patients with recurrence had lower preoperative concentrations of IgG and higher concentrations of C4 and C1-INH than disease-free patients.
- C1-INH was the most potent prognosticator with 80% accuracy in predicting recurrence.
- The predictive value of C1-INH was superior to the extent of disease.
- Preoperative C1-INH concentration reflects an additional prognostic feature appropriate to the tumor or the host.
Takeaway
Doctors can use a blood test to check a substance called C1-INH to help predict if a stomach cancer patient will get better or have problems after surgery.
Methodology
The study measured preoperative serum concentrations of IgG, IgA, IgM, C3, C4, and C1-INH in 99 patients who underwent surgery for gastric carcinoma.
Limitations
The study excluded patients with other diseases or a history of another malignant disease within the last 5 years.
Participant Demographics
Mean age was 66.1 years, with 40% women.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
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