Feasibility Study of Oesophageal Cancer in Golestan, Iran
Author Information
Author(s): Pourshams A, Saadatian-Elahi M, Nouraie M, Malekshah A F, Rakhshani N, Salahi R, Yoonessi A, Semnani S, Islami F, Sotoudeh M, Fahimi S, Sadjadi A R, Nasrollahzadeh D, Aghcheli K, Kamangar F, Abnet C C, Saidi F, Sewram V, Strickland P T, Dawsey S M, Brennan P, Boffetta P, Malekzadeh R
Primary Institution: Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences
Hypothesis
Is it feasible to conduct a cohort study on oesophageal cancer incidence in Golestan province, Iran?
Conclusion
The study confirmed that conducting a cohort study in Golestan is feasible with reliable information obtained for suspected risk factors.
Supporting Evidence
- Participants had a high participation rate of 78.4%.
- Reliability of questionnaire data was confirmed with κ values above 0.7 for most variables.
- Two cases of oesophageal cancer were identified during the follow-up period.
Takeaway
Researchers wanted to see if they could study oesophageal cancer in a part of Iran, and they found that many people were willing to help and share information.
Methodology
The study involved extensive lifestyle interviews and biological sample collection from participants aged 35-80 in Golestan province.
Potential Biases
Potential recall bias in self-reported lifestyle factors such as tobacco and opium use.
Limitations
The study was limited by the short follow-up period and the reliance on self-reported data for some lifestyle factors.
Participant Demographics
Participants included 610 women and 447 men, primarily of Turkmen ethnicity, aged 35-80.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website