Impact of ALDH1A1 Expression in Intrahepatic Cholangiocellular Carcinoma
Author Information
Author(s): Kurowski Konrad, Föll Melanie, Werner Tilman, Schilling Oliver, Werner Martin, Fichtner-Feigl Stefan, Bengsch Bertram, Bronsert Peter, Holzner Philipp Anton, Timme Sylvia
Primary Institution: University of Freiburg
Hypothesis
Does ALDH1A1 expression correlate with overall survival in intrahepatic cholangiocarcinoma?
Conclusion
ALDH1A1 overexpression in both tumor and stromal cells is associated with improved overall survival in intrahepatic cholangiocarcinoma.
Supporting Evidence
- ALDH1A1 overexpression correlates with favorable overall survival in iCC.
- Gender-specific analyses indicate a more pronounced effect in females.
- High ALDH1A1 expression in tumor and stromal cells is linked to longer patient survival.
Takeaway
This study found that a protein called ALDH1A1 can help predict how long patients with a specific type of liver cancer might live, especially in women.
Methodology
The study analyzed 69 patient samples using tissue microarrays and assessed ALDH1A1 expression through immunohistochemistry and machine learning algorithms.
Limitations
The study's findings need validation in larger cohorts.
Participant Demographics
34 male (51%); 35 female (49%); mean age 64 years (range 33 - 83).
Statistical Information
P-Value
p = 0.0068 for tumor; p = 0.008 for stroma
Confidence Interval
[1.22, 3.93] for tumor; [1.23, 4.67] for stroma
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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