Lotus Seed Extract and Its Anticancer Potential
Author Information
Author(s): Mallela Vijaya Jyothi, Rudrapal Mithun, Prasanth D. S. N. B. K., Pasala Praveen Kumar, Bendale Atul R., Bhattacharya Soumya, Aldosari Sahar M., Khan Johra
Primary Institution: Raghavendra Institute of Pharmaceutical Education and Research, Jawaharlal Nehru Technological University Anantapur, Anantapur, India
Hypothesis
Can lotus seed extracts inhibit ovarian cancer cell proliferation and induce apoptosis?
Conclusion
The methanolic extract of lotus seeds significantly inhibits ovarian cancer cell proliferation and induces apoptosis.
Supporting Evidence
- The methanolic extract of lotus seeds showed significant inhibition of ovarian cancer cell lines SKOV3 and A2780.
- Apoptosis was increased to 78% in A2780-CisR cells and 82% in SKOV3-CisR cells after treatment with the extract.
- GC-MS analysis identified 14 phytocompounds in the methanolic extract.
- Molecular docking revealed oleic acid and other compounds had strong binding affinities to survivin.
Takeaway
Lotus seeds can help fight cancer by stopping cancer cells from growing and making them die.
Methodology
The study involved in vitro tests on ovarian cancer cell lines, GC-MS analysis for phytochemical profiling, and molecular docking studies.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website