ASARM Mineralization Hypothesis: A Bridge Too Far?
2010
Understanding the ASARM Mineralization Hypothesis
Commentary
Evidence: low
Author Information
Author(s): David Valentin Quarles, L Darryl
Primary Institution: University of Tennessee Health Science Center
Hypothesis
Is the ASARM hypothesis a valid model for understanding bone mineralization?
Conclusion
The ASARM hypothesis may not accurately represent the complex mechanisms of bone mineralization.
Supporting Evidence
- The ASARM hypothesis suggests that certain peptides inhibit bone mineralization.
- Studies show that the bone phenotype of MEPE null mice does not support the ASARM hypothesis.
- Phosphorylated ASARM peptides may inhibit mineralization in vitro, but their physiological role is unclear.
Takeaway
This study looks at how certain proteins in bones might affect how bones get minerals. It questions if a new idea about this process is really true.
Limitations
The study highlights several discordant findings that challenge the ASARM hypothesis.
Digital Object Identifier (DOI)
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