GOLEM: A Tool for Gene Ontology Navigation and Analysis
Author Information
Author(s): Rachel SG Sealfon, Matthew A Hibbs, Curtis Huttenhower, Chad L Myers, Olga G Troyanskaya
Primary Institution: Princeton University
Hypothesis
No existing system provides an interactively expandable graph-based view of the gene ontology hierarchy.
Conclusion
GOLEM is a useful software tool for biologists interested in visualizing the local directed acyclic graph structure of the gene ontology hierarchy and searching for gene ontology terms enriched in genes of interest.
Supporting Evidence
- GOLEM allows users to dynamically expand and focus the local graph structure of the gene ontology hierarchy.
- It supports rapid analysis of an input list of genes to find enriched gene ontology terms.
- GOLEM can run without an Internet connection using local gene ontology and annotations files.
Takeaway
GOLEM helps scientists see and explore how genes are related in a big map, making it easier to find important information about genes.
Methodology
GOLEM is implemented in Java and uses a directed acyclic graph structure to visualize gene ontology hierarchies.
Limitations
GOLEM may not support all existing gene ontology tools and relies on user input for annotations.
Statistical Information
P-Value
p<0.05
Digital Object Identifier (DOI)
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