NEDD4L Gene Variation and Salt Sensitivity
Author Information
Author(s): Dahlberg Jonas, Nilsson Lars-Olof, von Wowern Fredrik, Melander Olle
Primary Institution: Department of Clinical Sciences, Malmö University Hospital and Lund University, Malmö, Sweden
Hypothesis
Is genetic variation in NEDD4L associated with increased salt sensitivity?
Conclusion
Genetic NEDD4L variation seems to affect salt sensitivity and P-renin in normotensive subjects.
Supporting Evidence
- Carriers of the rs4149601 GG-genotype had significantly higher salt sensitivity compared to non-carriers.
- Lower plasma renin concentration was observed in carriers of the rs4149601 GG-genotype.
- The study suggests that genotyping of NEDD4L may help identify individuals who would benefit from dietary salt restriction.
Takeaway
Some people are more sensitive to salt, and this study found that certain genes can help identify who they are.
Methodology
39 normotensive subjects were studied with a crossover design comparing high and low salt intake effects on blood pressure.
Limitations
The study had a small sample size and was limited to normotensive subjects.
Participant Demographics
39 healthy subjects (20 men and 19 women) with an average age of 53 years.
Statistical Information
P-Value
0.007
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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