Nrf2 Signaling in Renal Cell Carcinoma: A Potential Candidate for the Development of Novel Therapeutic Strategies
Author Information
Author(s): Schiavoni Valentina, Emanuelli Monica, Milanese Giulio, Galosi Andrea Benedetto, Pompei Veronica, Salvolini Eleonora, Campagna Roberto
Primary Institution: Polytechnic University of Marche
Hypothesis
Nrf2 could be a promising biomarker for predicting the course of renal cell carcinoma and a valuable therapeutic target.
Conclusion
Nrf2 plays a dual role in renal cell carcinoma, promoting tumor progression while also being a potential target for therapy.
Supporting Evidence
- Nrf2 is involved in various cancer-promoting functions such as proliferation and resistance to chemotherapy.
- Chronic activation of Nrf2 in renal cell carcinoma cells results in increased metastatic potential.
- Nrf2 can be a target for developing new therapies for renal cell carcinoma.
Takeaway
Nrf2 is a protein that helps cancer cells survive and grow, and targeting it might help treat kidney cancer better.
Methodology
This review analyzes existing literature on the role of Nrf2 in renal cell carcinoma and its implications for therapy.
Limitations
The review is based on existing studies and may not include all recent findings.
Digital Object Identifier (DOI)
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