Haoqin Qingdan Decoction Protects Against Lung and Gut Damage from Influenza
Author Information
Author(s): Lin Xi, Lin Jian, Ji Lichun, Zhang Jiaona, Zhang Yezi, Hong Junbin, Li Geng, Lin Xingdong
Primary Institution: Guangzhou University of Chinese Medicine
Hypothesis
Can Haoqin Qingdan decoction (HQQD) alleviate pulmonary and intestinal injuries caused by influenza viral pneumonia in mice?
Conclusion
HQQD effectively reduces lung and intestinal damage from influenza viral pneumonia through antiviral and anti-inflammatory actions.
Supporting Evidence
- HQQD significantly reduced NP protein expression in the lungs.
- HQQD alleviated immune damage in the lungs and intestines of mice.
- HQQD inhibited the release of inflammatory factors such as IL-6 and TNF-α.
- HQQD downregulated the expression levels of TLR7 and MyD88.
- HQQD improved the gut microbiota composition in infected mice.
Takeaway
This study shows that a traditional Chinese medicine called Haoqin Qingdan decoction helps protect mice from getting sick in their lungs and intestines when they have the flu.
Methodology
The study used ultra-high-performance liquid chromatography coupled with mass spectrometry (UHPLC-MS) to analyze the chemical constituents of HQQD and assessed its effects on mice infected with influenza A virus.
Limitations
The study was conducted in mice, and results may not directly translate to humans.
Participant Demographics
Male BALB/c mice, aged 36-42 days, weighing 18-22 g.
Statistical Information
P-Value
<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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