Glut-1 as a receptor for HTLV-1 and HTLV-2
Author Information
Author(s): Kinet Sandrina, Swainson Louise, Madakasira Lavanya, Mongellaz Cedric, Montel-Hagen Amélie, Craveiro Marco, Manel Nicolas, Battini Jean-Luc, Sitbon Marc, Taylor Naomi
Primary Institution: Institut de Génétique Moléculaire de Montpellier (IGMM)
Hypothesis
Does Glut-1 serve as a receptor for HTLV-1 and HTLV-2 on activated T cells?
Conclusion
Glut-1 is a primary binding receptor for HTLV-1 and HTLV-2 envelopes on activated CD4 and CD8 lymphocytes.
Supporting Evidence
- Glut-1 expression increases in activated T cells.
- HTLV-1 and HTLV-2 envelope binding is enhanced by Glut-1.
- Glut-1 is induced by TCR engagement in T cells.
Takeaway
Glut-1 helps the HTLV-1 and HTLV-2 viruses attach to certain immune cells, especially when those cells are activated.
Methodology
The study involved assessing Glut-1 expression and its binding to HTLV envelope proteins on activated T cells using flow cytometry and glucose uptake assays.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website