Psoriasis and Cancer: Understanding the Risks and Treatments
Author Information
Author(s): Mateescu Larisa-Alexandra, Savu Alexandra-Petruța, Mutu Costina-Cristiana, Vaida Cezara-Diana, Șerban Elena-Daniela, Bucur Ștefana, Poenaru Elena, Nicolescu Alin-Codruț, Constantin Maria-Magdalena
Primary Institution: 2nd Department of Dermatology, Colentina Clinical Hospital, Bucharest, Romania
Hypothesis
What is the relationship between psoriasis and the risk of developing cancer?
Conclusion
Psoriasis patients have an increased risk of certain cancers, and treatment strategies must balance effective psoriasis management with cancer risk.
Supporting Evidence
- Psoriasis patients have a higher incidence of certain cancers, such as lymphomas and skin cancers.
- Immunomodulatory treatments for psoriasis present varied cancer risks.
- Chronic inflammation in psoriasis may contribute to cancer development.
- Ethnicity influences the risk of skin cancer in psoriasis patients.
- IL-17 and IL-23 inhibitors may offer safer treatment options for psoriasis patients with a history of cancer.
Takeaway
People with psoriasis might get certain types of cancer more often, so doctors need to be careful when treating them.
Methodology
This review analyzes existing studies on the relationship between psoriasis and cancer risk, focusing on epidemiological evidence and treatment impacts.
Potential Biases
The studies reviewed may have biases due to the lack of diversity in participant demographics.
Limitations
The review highlights the need for more diverse studies to understand cancer risk across different ethnicities in psoriasis patients.
Participant Demographics
Psoriasis affects 2-3% of the global population, with varying prevalence based on age, gender, and ethnicity.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI, 4.02–5.59%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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