Dicholine Salt of Succinic Acid Improves Cognitive Function in Aging and Alzheimer's Models
Author Information
Author(s): Zinaida I. Storozheva, Andrey T. Proshin, Vladimir V. Sherstnev, Tatiana P. Storozhevykh, Yana E. Senilova, Nadezhda A. Persiyantseva, Vsevolod G. Pinelis, Natalia A. Semenova, Elena I. Zakharova, Igor A. Pomytkin
Primary Institution: P.K. Anokhin Institute of Normal Physiology, RAMS, Moscow, Russia
Hypothesis
Can dicholine salt of succinic acid enhance insulin receptor signaling and ameliorate cognitive deficits in animal models?
Conclusion
Dicholine salt of succinic acid improves cognitive deficits and neuronal dysfunctions in animal models relevant to age-related cognitive impairments, vascular dementia, and Alzheimer's disease.
Supporting Evidence
- Dicholine salt of succinic acid significantly enhanced insulin-stimulated insulin receptor autophosphorylation in neurons.
- CS improved spatial learning and memory in middle-aged mice and rats with cognitive deficits.
- CS treatment resulted in increased brain N-acetylaspartate/creatine levels, indicating improved neuronal function.
Takeaway
A special substance called dicholine salt of succinic acid can help older animals think better and remember things more easily.
Methodology
The study involved administering dicholine salt of succinic acid to various rodent models and assessing cognitive performance through behavioral tests and brain chemistry analysis.
Participant Demographics
The study used middle-aged C57Bl/6 mice and Wistar rats.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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