Emericella quadrilineata as Cause of Invasive Aspergillosis
Author Information
Author(s): Verweij Paul E., Varga János, Houbraken Jos, Rijs Antonius J.M.M., VerduynLunel Frans M., Blijlevens Nicole M.A., Shea Yvonne R., Holland Steven M., Warris Adilia, Melchers Willem J. G., Samson Robert A.
Primary Institution: Radboud University Nijmegen Medical Center
Hypothesis
Is Emericella quadrilineata a significant causative agent of invasive aspergillosis?
Conclusion
Sequence-based identification is more accurate than morphologic examination for identifying Emericella spp., which can affect patient management.
Supporting Evidence
- E. quadrilineata was less susceptible to caspofungin than E. nidulans.
- Sequence-based identification revealed that 50% of E. quadrilineata isolates had been misidentified as E. nidulans.
- Four cases of infection or colonization by E. quadrilineata were identified in a 3-month period.
Takeaway
This study found that a fungus called Emericella quadrilineata can cause serious infections, and it's often confused with a similar fungus, making it important to identify the right one.
Methodology
The study involved sequence-based analysis of 33 Emericella isolates to identify species and assess antifungal susceptibility.
Limitations
The resolution of sequencing of the ITS region is too low to reliably differentiate between E. nidulans and E. quadrilineata.
Participant Demographics
Included patients with chronic granulomatous disease and other immunocompromised conditions.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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