Sirolimus and Bladder Cancer Cells
Author Information
Author(s): Pinto-Leite Rosario, Botelho Pedro, Ribeiro Eufemia, Oliveira Paula A, Santos Lucios
Primary Institution: Genetic Service, Cytogenetic laboratory, Hospital center of Trás-os-Montes and Alto Douro
Hypothesis
Can sirolimus inhibit the growth of T24 bladder cancer cells?
Conclusion
Sirolimus has an anti-proliferation effect on the T24 bladder carcinoma cell line.
Supporting Evidence
- Sirolimus inhibits the growth of bladder carcinoma cells.
- Significant correlations were found between cell proliferation and sirolimus concentration.
- Cell viability decreased with increasing concentrations of sirolimus.
Takeaway
Sirolimus is a drug that can help stop bladder cancer cells from growing.
Methodology
T24 bladder cancer cells were treated with various concentrations of sirolimus, and cell proliferation and viability were assessed using MTT assay and Trypan blue exclusion analysis.
Limitations
The study is preliminary and requires further research to confirm the findings.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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