Activation of Dopamine Reward Pathways for Treating Reward Deficiency Syndrome
Author Information
Author(s): Kenneth Blum, Amanda Lih Chuan Chen, Thomas JH Chen, Eric R Braverman, Jeffrey Reinking, Seth H Blum, Kimberly Cassel, Bernard W Downs, Roger L Waite, Lonna Williams, Thomas J Prihoda, Mallory M Kerner, Tomas Palomo, David E Comings, Howard Tung, Patrick Rhoades, Marlene Oscar-Berman
Hypothesis
The treatment of multiple addictions should involve a biphasic approach, combining blocking and activating dopamine receptors.
Conclusion
Long-term activation of the mesolimbic dopaminergic system can help reduce cravings and treat behaviors associated with Reward Deficiency Syndrome.
Supporting Evidence
- Research shows that stimulating dopamine receptors can lead to increased receptor proliferation.
- Studies indicate that individuals with certain genetic predispositions are more likely to develop addiction behaviors.
- Long-term dopaminergic activation can modify behaviors associated with substance use disorders.
Takeaway
This study suggests that to help people with addiction, we should activate certain brain pathways instead of just blocking them.
Digital Object Identifier (DOI)
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