Phenylalanine Protects Against Stomach Cancer in Rats
Author Information
Author(s): H. Tishi, M. Tatsuta, M. Baba, S. Okuda, H. Taniguchi
Primary Institution: The Center for Adult Diseases, Osaka
Hypothesis
Does oral phenylalanine reduce the incidence of gastric adenocarcinomas induced by a carcinogen in rats?
Conclusion
Oral administration of phenylalanine significantly reduced the incidence and number of gastric cancers in rats treated with a carcinogen.
Supporting Evidence
- Phenylalanine significantly reduced the incidence of adenocarcinomas in the stomach.
- Rats receiving phenylalanine had lower labelling indices of gastric mucosa.
- High-dose phenylalanine increased serum gastrin levels.
Takeaway
Giving rats a special amino acid called phenylalanine helped protect them from getting stomach cancer caused by a harmful chemical.
Methodology
Young male Wistar rats were treated with a carcinogen for 25 weeks and then given either regular food or food with added phenylalanine for 26 weeks.
Limitations
The study was conducted on rats, and results may not directly apply to humans.
Participant Demographics
Young male Wistar rats, aged about 6 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website