The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life
Author Information
Author(s): Atkinson Gemma C., Tenson Tanel, Hauryliuk Vasili, Stiller John W.
Primary Institution: University of Tartu, Institute of Technology, Tartu, Estonia
Hypothesis
How do RSH proteins evolve and function across different organisms?
Conclusion
The study classifies RSH proteins into 30 subgroups and provides insights into their evolutionary history and functional diversity.
Supporting Evidence
- RSH proteins are involved in synthesizing and hydrolyzing ppGpp, a key regulator of bacterial metabolism.
- The study identified 30 subgroups of RSH proteins, expanding the understanding of their diversity.
- Phylogenetic analysis revealed evolutionary relationships among RSH proteins across different domains of life.
Takeaway
Scientists studied a family of proteins that help bacteria respond to stress, finding many different types across various organisms.
Methodology
High-throughput sequence searching and phylogenetic analyses of over 1000 genomes.
Potential Biases
Potential biases in the selection of genomes and sequences for analysis.
Limitations
The study may not cover all RSH proteins due to the limited number of genomes analyzed.
Participant Demographics
The study includes a wide range of organisms from bacteria to plants.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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