Prostate Cancer and Sexual Function with Anti-Androgens
Author Information
Author(s): Schröder F H, Collette L, Reijke T M de, Whelan P
Primary Institution: Erasmus University and Academic Hospital
Hypothesis
Is sexual function preserved in prostate cancer patients treated with anti-androgens?
Conclusion
Both anti-androgens lead to a slow decline in sexual function, with some men retaining sexual activity after several years.
Supporting Evidence
- 294 out of 310 randomized patients were eligible for evaluation.
- Sexual functions at entry were similar in both treatment groups.
- 80% of men under FLU and 92% under CPA lost spontaneous erections after treatment.
Takeaway
This study looked at how prostate cancer treatments affect men's sexual function, finding that while many men lose sexual function over time, some can still be active after years of treatment.
Methodology
Open, prospective, randomized study evaluating sexual function in patients treated with flutamide or cyproterone acetate.
Limitations
Final analysis of time to progression and survival is still pending.
Participant Demographics
Median age of participants was 71 years, with a range of 48 to 85 years.
Digital Object Identifier (DOI)
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