Interleukin-6 Levels in Oesophageal Cancer
Author Information
Author(s): Wang L-S, Chow K-C, Wu C-W
Primary Institution: Veterans General Hospital in Taipei and National Yang-Ming University, Taipei, Taiwan, ROC
Hypothesis
The study aims to identify the source and clinical roles of serum IL-6 in patients with oesophageal squamous cell carcinoma (ESCC) and to characterize the biological regulation of IL-6 in ESCC cell lines.
Conclusion
The serum levels of IL-6 are frequently elevated at diagnosis of ESCC and are associated with poor prognosis.
Supporting Evidence
- Serum levels of IL-6 in patients with ESCC were significantly higher than those in healthy controls.
- Serum levels of IL-6 correlated with disease progression and survival.
- IL-6 gene expression and protein production could be induced by n-sodium butyrate treatment in ESCC cell lines.
Takeaway
This study found that people with a type of throat cancer have higher levels of a substance called IL-6 in their blood, which can mean the cancer is worse.
Methodology
Sera and tissue specimens from 80 patients were collected, and IL-6 levels were measured using ELISA; in vitro studies were conducted on ESCC cell lines.
Participant Demographics
Patients with oesophageal squamous cell carcinoma (ESCC).
Digital Object Identifier (DOI)
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