Comparing SNPs and Microsatellites for Genome Scans
Author Information
Author(s): Lin Jennifer, Liu Kuang-Yu
Primary Institution: Brigham and Women's Hospital, Harvard Medical School
Hypothesis
Can a SNP marker set be as useful as a traditional microsatellite marker set for linkage-based genome scans?
Conclusion
The SNP-based genome scan has the potential to be as powerful as the traditional microsatellite-based scan.
Supporting Evidence
- Both SNP and microsatellite scans identified a similar number of chromosomal regions with nominal significance.
- Confirmed linkage evidence was found for chromosome 1 in AI families and chromosomes 1 and 3 in DA families.
- Fine-mapped association analysis identified markers significantly associated with disease status in each population.
Takeaway
This study looked at two ways to find genes that might cause diseases, using different types of markers. They found that both methods work well, but the SNP method might be just as good as the older method.
Methodology
The study compared linkage results from SNPs and microsatellites in 300 nuclear families across three populations using genome-wide scans.
Limitations
The SNP scan had lower information content compared to the microsatellite scan.
Participant Demographics
Nuclear families from Aipotu, Danacaa, and Karangar populations.
Statistical Information
P-Value
2 × 10-5
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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