FAVOURED Study: Preventing AVF Thrombosis with Omega-3 Fatty Acids and Aspirin
Author Information
Author(s): Irish Ashley, Dogra Gursharan, Mori Trevor, Beller Elaine, Heritier Stephane, Hawley Carmel, Kerr Peter, Robertson Amanda, Rosman Johan, Paul-Brent Peta-Anne, Starfield Melissa, Polkinghorne Kevan, Cass Alan
Primary Institution: Renal Unit, Royal Perth Hospital, Perth, WA, Australia
Hypothesis
Will the use of aspirin and omega-3 fatty acids reduce the risk of early thrombosis in de novo arteriovenous fistulas?
Conclusion
The study aims to determine if aspirin and omega-3 fatty acids can improve the patency of arteriovenous fistulas in patients undergoing hemodialysis.
Supporting Evidence
- Haemodialysis critically depends on adequate vascular access.
- Primary failure rates of AVF can range from 20% to 54% due to thrombosis.
- Previous studies have shown mixed results regarding the efficacy of anti-platelet agents.
Takeaway
This study is trying to find out if taking fish oil and aspirin can help keep a special type of blood vessel open for people who need dialysis.
Methodology
A randomized, double-blind, placebo-controlled trial with a factorial design comparing aspirin and omega-3 fatty acids against placebos.
Potential Biases
Potential biases related to patient selection and adherence to treatment protocols.
Limitations
The study may not be adequately powered to detect clinically important differences between the combination treatment and either treatment alone.
Participant Demographics
Adults with stage IV or V chronic kidney disease, currently on or about to start hemodialysis.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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