Changes in PD-1 Expression in Esophageal Cancer Patients After Chemoradiotherapy
Author Information
Author(s): Xueling Shi, Hongyu Zhao, Jiaqi Yu, Peng Cai, Shixiang Zhou, Ning Yang, Duojie Li
Primary Institution: The First Affiliated Hospital of Bengbu Medical University
Hypothesis
This study aimed to observe the dynamic changes in the expression of T lymphocytes, natural killer (NK) cells, and PD-1 in patients with first-diagnosed esophageal squamous cell carcinoma (ESCC) before and after chemoradiotherapy (CRT).
Conclusion
Chemoradiotherapy (CRT) aggravated immunosuppression and increased PD-1 expression in T lymphocyte subsets in patients with ESCC.
Supporting Evidence
- PD-1 expression in CD3+, CD4+, and CD8+ T cells significantly decreased in patients achieving overall response rate.
- Patients with lower PD-1 expression in the peripheral blood had better short-term outcomes.
- Chemoradiotherapy reduced the overall immune function of patients with esophageal squamous cell carcinoma.
Takeaway
Doctors looked at how treatment affects the immune system in patients with esophageal cancer. They found that the treatment made some immune cells weaker and increased a marker called PD-1, which can help predict how well the treatment works.
Methodology
Flow cytometry was used to detect PD-1 expression in the peripheral blood and related immune indicators before and after CRT.
Limitations
The study had a relatively small sample size and limited number of healthy controls.
Participant Demographics
Of the 73 patients, 44 were male (60.27%) and 29 were female (39.73%), with an average age of 76.42 years.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website