Extensively Drug-Resistant Tuberculosis in China
Author Information
Author(s): Deng Yunfeng, Wang Yan, Wang Junling, Jing Hui, Yu Chunbao, Wang Haiying, Liu Zhimin, Graviss Edward A., Ma Xin
Primary Institution: Shandong Provincial Chest Hospital
Hypothesis
What is the prevalence of extensively drug-resistant tuberculosis (XDR TB) in China?
Conclusion
The study found that 18.7% of multidrug-resistant tuberculosis strains in Shandong Province met the definition for XDR TB, which is higher than previous estimates in China.
Supporting Evidence
- 32.3% of the analyzed isolates were resistant to at least one first-line drug.
- 10.8% of the isolates were multidrug resistant.
- 18.7% of the multidrug-resistant isolates were classified as extensively drug-resistant.
Takeaway
This study looked at a lot of tuberculosis samples in China and found that many of them were really hard to treat because they were resistant to many drugs.
Methodology
The study analyzed drug-resistance profiles of 989 clinical Mycobacterium tuberculosis isolates collected from inpatients over a period from November 2004 to April 2007.
Potential Biases
The data collection was based in a TB hospital, which may not represent the general population's TB cases.
Limitations
The study may overestimate the prevalence of XDR and MDR TB due to a higher proportion of previously treated patients compared to other studies.
Participant Demographics
The mean age of participants was 40.1 years, with 65.5% being male.
Digital Object Identifier (DOI)
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