MRP-1/CD9 and KAI1/CD82 in Oesophageal Cancer
Author Information
Author(s): Uchida S, Shimada Y, Watanabe G, Li Z Gang, Hong T, Miyake M, Imamura M
Primary Institution: Graduate School of Medicine, Kyoto University
Hypothesis
The expression of MRP-1/CD9 and KAI1/CD82 inversely correlates with lymph node metastasis in oesophageal squamous cell carcinoma.
Conclusion
Reduced expression of MRP-1/CD9 and KAI1/CD82 is associated with worse prognosis and increased lymph node metastasis in oesophageal squamous cell carcinoma.
Supporting Evidence
- Reduced MRP-1/CD9 expressions significantly correlated to tumour depth.
- A significantly greater number of reduced or negative expression of MRP-1/CD9 and KAI1/CD82 was found in lymph node metastatic cases.
- The 5-year survival rate of MRP-1/CD9-negative patients was significantly worse than those of positive patients.
Takeaway
This study found that lower levels of certain proteins in oesophageal cancer cells can mean the cancer is more likely to spread to lymph nodes, which is not good for patients.
Methodology
Immunohistochemical staining was performed on 108 cases of oesophageal squamous cell carcinoma and 24 dysplasias to assess the expression of MRP-1/CD9 and KAI1/CD82.
Statistical Information
P-Value
P = 0.0009, P = 0.0003, P = 0.0129
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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