CD64 and CD163 Expression in Critically Ill Children with Sepsis
Author Information
Author(s): Mojca Groselj-Grenc, Ihan Alojz, Derganc Metka
Primary Institution: University Medical Center, Slovenia
Hypothesis
Can CD64 and CD163 expression on neutrophils and monocytes discriminate between infectious and noninfectious SIRS in critically ill neonates and children?
Conclusion
CD64 and CD163 expressions on neutrophils and monocytes are elevated in critically ill neonates and children with SIRS with sepsis, and CD64 index for neutrophils is the most effective marker.
Supporting Evidence
- CD64 and CD163 expressions were significantly higher in patients with SIRS with sepsis compared to those without.
- Diagnostic accuracy of CD64 index for neutrophils was superior to other markers.
- Statistically significant differences were found in CD64 and CD163 MFI between the two groups.
Takeaway
Doctors can use special markers in the blood to tell if very sick babies and kids have an infection or not.
Methodology
This was a prospective observational study measuring CD64 and CD163 expressions using flow cytometry in critically ill neonates and children with SIRS and suspected sepsis.
Potential Biases
Potential bias in the classification of patients by attending physicians unaware of flow cytometry results.
Limitations
The study had a relatively small sample size and the definition of clinical sepsis in culture-negative patients is debatable.
Participant Demographics
Participants included 56 critically ill neonates and children, with 29 having SIRS with sepsis and 27 without.
Statistical Information
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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