Genetic Variant in HK1 and Its Relation to Type 2 Diabetes and Metabolic Traits
Author Information
Author(s): Gjesing Anette P, Nielsen Aneta A, Brandslund Ivan, Christensen Cramer, Sandbæk Anneli, Jørgensen Torben, Witte Daniel, Bonnefond Amélie, Froguel Phillippe, Hansen Torben, Pedersen Oluf
Primary Institution: The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen
Hypothesis
The study aims to investigate the effect of HK1 rs7072268 on glucose and lipid metabolism and its association with type 2 diabetes.
Conclusion
The study suggests that the rs7072268 T-allele in HK1 is associated with increased glucose levels and a nominal association with type 2 diabetes.
Supporting Evidence
- The T-allele of rs7072268 was associated with an increase in HbA1c of 0.6% per allele.
- The same allele was linked to an increased area under the curve for glucose following an oral glucose tolerance test.
- Carriers of the T-allele showed a higher prevalence of type 2 diabetes in the study population.
Takeaway
A specific gene variant may make some people more likely to have higher blood sugar and cholesterol levels, which could lead to diabetes.
Methodology
The study involved genotyping SNP rs7072268 in a large Danish population and included both quantitative trait analysis and case-control studies.
Limitations
The study may be underpowered to detect minor effects of the variant on glucose homeostasis.
Participant Demographics
Participants were Danish Caucasians, including both non-diabetic individuals and type 2 diabetes patients.
Statistical Information
P-Value
3*10-7
Confidence Interval
0.4 - 0.9
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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