Overcoming Multidrug Resistance in Human Cancer Cells by Natural Compounds
2010
Natural Compounds to Overcome Cancer Drug Resistance
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Nabekura Tomohiro
Primary Institution: Niigata University of Pharmacy and Applied Life Sciences
Hypothesis
Can natural compounds inhibit P-glycoprotein to reverse multidrug resistance in cancer cells?
Conclusion
Natural compounds like curcumin and EGCG can inhibit P-glycoprotein, potentially reversing drug resistance in cancer treatment.
Supporting Evidence
- Natural compounds can increase the sensitivity of cancer cells to anticancer drugs.
- Phytochemicals like curcumin and EGCG have been shown to inhibit P-glycoprotein.
- Tea catechins can enhance the accumulation of anticancer drugs in resistant cancer cells.
- Curcumin has been extensively studied for its chemopreventive properties.
Takeaway
Some natural foods can help cancer medicines work better by stopping cancer cells from pushing the medicine out.
Methodology
The review summarizes studies on the effects of various natural compounds on P-glycoprotein and other ABC transporters.
Limitations
The review does not provide specific clinical trial data or in vivo results.
Digital Object Identifier (DOI)
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