Model of Serum Anti-Müllerian Hormone from Conception to Menopause
Author Information
Author(s): Kelsey Thomas W., Wright Phoebe, Nelson Scott M., Anderson Richard A., Wallace W. Hamish B.
Primary Institution: University of St. Andrews
Hypothesis
What is the pattern of serum Anti-Müllerian Hormone (AMH) concentrations in healthy females from conception to menopause?
Conclusion
The study provides a validated model showing that serum AMH concentrations peak at age 24.5 years and decline thereafter, reflecting ovarian reserve.
Supporting Evidence
- 34% of the variation in AMH is due to age alone.
- AMH concentrations peak at age 24.5 years.
- The model allows for generating normative data at all ages.
- Serum AMH falls shortly after birth and increases again after two years.
- AMH reflects the progressive loss of the non-growing follicle pool.
- The model is validated using standard mathematical techniques.
- Data was collected from over 3,500 subjects.
- The model can be used to interpret serum AMH concentrations across the female lifespan.
Takeaway
This study created a model to show how a hormone related to female fertility changes from birth to menopause, helping to understand women's reproductive health.
Methodology
The model was derived from 3,260 data points collected from published studies and original data, validated using 10-fold cross-validation.
Potential Biases
Potential bias from the health status of subjects in the studies used and the accuracy of graphical data extraction.
Limitations
The study relies on data from published literature, which may have inaccuracies regarding the health status of subjects.
Participant Demographics
Healthy pre-menopausal females, with data ranging from cord blood to ages up to 54.3 years.
Statistical Information
P-Value
0.34
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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