Foscarnet Therapy for EBV Infection in Lung Transplant Recipient
Author Information
Author(s): Kamyar Afshar, A. Purush Rao, Vipul Patel, Kevin Forrester, Sivagini Ganesh
Primary Institution: University of Southern California
Hypothesis
Can foscarnet effectively control EBV infection in a lung transplant recipient with PTLD?
Conclusion
Foscarnet combined with immunoglobulins successfully cleared the EBV infection in a lung transplant recipient with PTLD.
Supporting Evidence
- Reduction in immunosuppression improved PTLD but did not control EBV infection.
- Foscarnet was effective in reducing EBV DNA levels to undetectable levels.
- This is the second reported case of successful EBV infection control using foscarnet.
Takeaway
A woman who had a lung transplant got sick from a virus called EBV. Doctors tried to help her by lowering her medicine that suppresses her immune system, but it didn't work until they used a special medicine called foscarnet.
Methodology
Case report detailing the treatment of a lung transplant recipient with EBV-associated PTLD using foscarnet and immunoglobulins.
Limitations
Only one case is reported, limiting generalizability.
Participant Demographics
24-year-old woman, lung transplant recipient.
Digital Object Identifier (DOI)
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