Reactome: A Knowledge Base of Biological Pathways and Processes
Author Information
Author(s): Vastrik Imre, D'Eustachio Peter, Schmidt Esther, Joshi-Tope Geeta, Gopinath Gopal, Croft David, de Bono Bernard, Gillespie Marc, Jassal Bijay, Lewis Suzanna, Matthews Lisa, Wu Guanming, Birney Ewan, Stein Lincoln
Primary Institution: European Bioinformatics Institute
Conclusion
Reactome serves as a comprehensive online resource for human biological pathways, enabling the inference of equivalent reactions in non-human species and aiding in the interpretation of high-throughput data.
Supporting Evidence
- Reactome provides infrastructure for computation across the biological reaction network.
- The database allows researchers to visualize pathway models and run simulations.
- Reactome is used to infer equivalent reactions in multiple nonhuman species.
- The knowledge base is heavily curated to ensure low rates of false reactions.
Takeaway
Reactome is like a big online book that helps scientists understand how different parts of living things work together, and it can also help compare these processes in other animals.
Methodology
The Reactome database is curated by expert biologists who collect, verify, and organize information about biological processes into a structured format.
Limitations
The inference of pathways in non-human species may not always be accurate due to evolutionary changes and the limitations of the clustering algorithms used.
Digital Object Identifier (DOI)
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