How Tumor Location Affects Weight Loss in Mice
Author Information
Author(s): Matsumoto T, Fujimoto-Ouchi K, Tamura S, Tanaka Y, Ishitsuka H
Primary Institution: Nippon Roche Research Center
Hypothesis
The site of tumor inoculation influences the induction of cachexia in mice with colon 26 carcinoma.
Conclusion
Tumors in different locations cause varying levels of cachexia in mice, with subcutaneous tumors leading to significant weight loss and high IL-6 levels, while liver tumors do not.
Supporting Evidence
- Mice with subcutaneous tumors showed significant weight loss and high levels of IL-6.
- Tumors in the liver did not cause cachexia despite being larger.
- Histological differences were observed between tumors grown in different locations.
Takeaway
Where a tumor grows in a mouse can change how sick it makes the mouse; some spots make the mouse lose a lot of weight, while others don't.
Methodology
Mice were inoculated with colon 26 carcinoma at different sites (subcutaneous, intramuscular, and liver) to observe the effects on cachexia and IL-6 levels.
Participant Demographics
Mice bearing colon 26 carcinoma.
Digital Object Identifier (DOI)
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